DNA Core Test + Consultation

This test and consultation service is available for individuals who meet the following criteria:

• Must be at least 18 years of age.

• Not currently pregnant or breastfeeding.

• No diagnosed active kidney disease, cancer, or eating disorder.

• Must reside outside the USA and Canada.

If you are unsure whether you meet these requirements, please contact me before purchasing.

The DNA Core® Test provides a 360-degree view of your genetic makeup across four key areas, helping you make informed decisions to support your long-term health:

1. Biological Processes and Disease Risk: Insights into key biological processes like metabolism, detoxification, and inflammation—factors that influence overall health and disease risk.

2. Nutrition & Food Sensitivities: Personalised nutrient requirements and risks for food sensitivities (caffeine and salt) and intolerances (gluten and lactose).

3. Weight Management: Genetic predispositions for weight gain, snacking behaviours, and circadian rhythm influences on metabolism.

4. Exercise & Recovery: Your body’s response to exercise, including fat mobilisation, endurance potential, injury risk, and recovery time.

• Focused, Reliable Results: DNA Core® analyses 70+ clinically relevant SNPs, each rigorously validated through double- or triple-pass testing for the highest accuracy and reliability. By focusing solely on proven and actionable SNPs, it avoids the complexity and inaccuracies often associated with broader genetic tests, delivering insights that directly inform your personalised health plan.

• Expert Guidance: A one-on-one consultation with a certified Nutrigenetic Counsellor ensures you fully understand your results and receive the support you need to take actionable steps toward achieving your health goals.

• Clinically Proven Interventions: Every SNP included in the DNA Core® Test is backed by strong scientific evidence, providing clear and actionable pathways to optimise your health—whether it’s refining your diet, managing inflammation, or improving detoxification.

This test is ideal for individuals seeking personalised health insights for:

• Weight Management: Understanding genetic influences on metabolism, appetite, and body weight.

• Energy & Fitness: Tailoring exercise, recovery, and energy optimisation based on genetic traits.

• Nutritional Needs: Identifying how your body processes macronutrients, vitamins, and minerals.

• Chronic Conditions: Exploring genetic predispositions to conditions like diabetes, cardiovascular disease, or other health risks.

• Proactive Health: For those looking to make informed lifestyle choices and optimise their overall health and well-being.

• Lipid Metabolism 

  APOC3: Cholesterol metabolism.

  APOE: Catabolism of triglyceride-rich lipoprotein constituents. Affects antioxidant requirement.

  CETP: Metabolism of HDL and mediates the exchange of lipids between lipoproteins.

  LPL: Removes lipids from the circulation by hydrolysing triglycerides into free fatty acids.

  PON1: Protects against atherogenesis by assisting in the cardioprotective effect of HDL.

• Insulin Sensitivity

  PPARG: Involved in adipocyte differentiation and regulation of glucose and lipid metabolism.

  TCF7L2: Influences blood glucose homeostasis – both insulin secretion and resistance.

  SLC2A2: Facilitates glucose induced insulin secretion.

  FTO: Influences susceptibility to obesity and risk for type 2 diabetes.

  IRS1: Involved in transmission of insulin-based signals.

• Methylation

  MTHFD1: Influences the effectiveness of the folate-dependent methylation pathway.

  MTHFR: Directs folate from the diet either to DNA synthesis or homocysteine remethylation.

  MTR: Catalyses the re-methylation of homocysteine to methionine.

  MTRR: Catalyses methylcobalamin, which is essential for maintaining adequate intracellular pools of methionine.

  CBS: Removal of homocysteine from the methionine cycle.

  COMT: Catalyses the transfer of a methyl group from S-adenosylmethionine to catecholamines.

• Phase I Detoxification

  CYP1A1: Converts environmental pro-carcinogens into reactive intermediates that have carcinogenic effects.

• Phase I Detoxification - Caffeine

  CYP1A2: Responsible for the demethylation of caffeine.

• Phase II Detoxification

  GSTM1 & GSTP1: Responsible for the removal of xenobiotics, carcinogens, and products of oxidative stress.

  GSTT1: Catalyses the conjugation of reduced glutathione.

  NQO1: Detoxification of potentially mutagenic and carcinogenic quinones derived from tobacco smoke, diet and oestrogen metabolism.

• Antioxidant Enzymes

  eNOS: Influences vascular tone and peripheral vascular resistance.

  MnSOD/SOD2: Vital antioxidant activity within the cell, especially within the mitochondria.

  GPx: Important selenium-dependant antioxidant enzymes.

  CAT: Responsible for the conversion of hydrogen peroxide to water and oxygen.

• Inflammation

  CRP: Rises in response to inflammation in the body.

  IL-1A, IL-1B & IL-1RN: Important leverage points in the inflammatory cascade.

  IL-6 & IL-6R: Plays crucial roles in inflammation by regulating the expression of C reactive protein (CRP).

  TNFA:  Crucial proinflammatory cytokine.

• Vitamin D metabolism & Bone Health

  VDR:  Profound influence on bone density.

  CYP2R1: Involved in the conversion of vitamin D to 25(OH)D (calcidiol).

  GC: Encodes for the vitamin D binding protein.

• Vitamin A Metabolism

  BC01: Catalysing carotenoids to retinal (vitamin A).

• Vitamin B12 Transport

  FUT2: Vitamin B12 absorption and transport.

• Lactose Intolerance

  MCM6: Associated with lactase persistence and adult hypolactasia.

• Gluten Intolerance

  HLA DQ2/DQ8: Major genetic predisposition for coeliac disease.

• Alcohol Metabolism

  ALDH2: Detoxification of toxic, carcinogenic aldehydes to acetate.

• Iron Overload

  HFE: Major genetic predisposition for hemochromatosis.

• Fat Absorption & Metabolism

  ADIPOQ: Regulates energy homeostasis and glucose tolerance thus promoting lipid oxidation in the muscle and liver.

  APOA2 & APOA5: Plays a complex role in lipoprotein metabolism, insulin resistance, obesity and atherosclerosis susceptibility.

  FABP2: Influences fat absorption and metabolism.

  PLIN: Influences diet-induced obesity.

• Polyunsaturated Fatty Acid Metabolism

  FADS1: Key enzyme in polyunsaturated fatty acid (PUFA) metabolism.

• Energy Homeostasis

  UCP1, UCP2 & UCP3: Involved in oxidative metabolism and energy production.

• Epinephrine Receptors - Energy Mobilisation

  ADRB2: Associated with blood vessel growth.

  ADBR3: Involved in the regulation of lipolysis that influences metabolism.

• Dopamine Receptor

  DRD2: Important role in both addiction and normal eating behaviour.

• Taste Sensitivity

  TAS1R2 & TAS2R38: Contribute to inter-individual variations in sugar consumption and bitter sensitivity.

• Snacking & Satiety

  MCR4: A strong obesity candidate gene.

• Circadian Rhythms

  CLOCK: Effect on circadian rhythms and sleep duration.

• Blood Flow & Respiration

  AGT & ACE: Part of the renin-angiotensin system and response to salt.

  BDKRB2: Influences the cross-talk between the renin-angiotensin and the kinin-kallikrein systems.

  VEGF: Affects peripheral circulation and capillary blood flow.

• Energy During Exercise

  NRF-2: Improves respiratory capacity and increases ATP production.

  PPARGC1A: Mediation of the initial phase of exercise and increasing mitochondrial biogenesis.

  PPARA: Associated with lipid and glucose metabolism.

• Fuel During Exercise

  TRHR: Stimulates the release of TSH.

• Musculoskeletal Properties

  ACTN3: Influences the function of fast-twitch muscle fibres.

• Muscle Cramping Susceptibility

  AMPD1: Muscle fatigue, weakness and cramping.

• Collagen Production

  COL1A1 & COL5A1: Found in tendons, ligaments and cartilage.

  GDF5: Development and healing of the skeletal system and soft tissues.

1. Order Your Test
   Purchase the DNA Core (Test + Consultation). Your test kit will be shipped to you within 7 days of payment.

2. Complete Your Intake Forms

   You’ll complete a detailed intake questionnaire covering your health concerns, medical history, medications, and stressors. You’ll also track your food habits over three days to provide a clear picture of your current routines.

3. Collect Your Sample
   Once your kit arrives, follow the simple instructions to collect your bloodspot sample using a quick finger prick test. Use the prepaid shipping label to return your sample to the lab. Bloodspot cards are highly stable, ensuring top-quality results during shipment.

4. Wait for Sample Analysis
   Your results will typically be ready in 18 days (+/- 5 days). Once available, I’ll contact you to schedule our session.

5. 90-Minute Consultation
   During our one-on-one consultation, we’ll review your genetic results and discuss what they mean and what you can do to optimise your genetic expression. Together, we’ll create a personalised plan tailored to your specific goals and needs.

6. Follow Your Plan
   After the consultation, you’ll receive a detailed report with actionable recommendations, including targeted dietary changes, supplements, and lifestyle strategies to support your overall well-being.

All DNALife samples are destroyed after 3 months, and no personal data is shared with third parties.